Co-exposure to an Aryl Hydrocarbon Receptor Endogenous Ligand, 6-Formylindolo[3,2-b]carbazole (FICZ), and Cadmium Induces Cardiovascular Developmental Abnormalities in Mice

@article{Omidi2018CoexposureTA,
  title={Co-exposure to an Aryl Hydrocarbon Receptor Endogenous Ligand, 6-Formylindolo[3,2-b]carbazole (FICZ), and Cadmium Induces Cardiovascular Developmental Abnormalities in Mice},
  author={Mahmoud Omidi and Hossein Niknahad and Ali Noorafshan and Reza Fardid and Elham Nadimi and Samaneh Naderi and Azizollah Bakhtari and Afshin Mohammadi-Bardbori},
  journal={Biological Trace Element Research},
  year={2018},
  volume={187},
  pages={442-451}
}
Abstract6-Formylindolo[3,2-b]carbazole (FICZ) is a signal substance and an endogenous activator of aryl hydrocarbon receptor (AHR). Cadmium (Cd) is an environmental pollutant that can activate both AHR and Wnt/β-catenin signaling pathways. We aimed to determine how dysregulated signaling through AHR-Wnt/β-catenin cross-talk can influence mice heart development. Mice fetuses were exposed to Cd alone or in combination with FICZ in gestation day (GD) 0. In GD18, fetuses were harvested and randomly… CONTINUE READING

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