Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design

@inproceedings{Rantalainen2018CoevolutionOH,
  title={Co-evolution of HIV Envelope and Apex-Targeting Neutralizing Antibody Lineage Provides Benchmarks for Vaccine Design},
  author={Kimmo Rantalainen and Zachary Berndsen and Sasha Murrell and Liwei Cao and Oluwarotimi Omorodion and Jonathan L Torres and Mengyu Wu and Jeffrey Umotoy and Jeffrey Copps and Pascal Poignard and Elise Landais and James C. Paulson and Ian A. Wilson and Andrew B. Ward},
  booktitle={Cell reports},
  year={2018}
}
Broadly neutralizing antibodies (bnAbs) targeting the HIV envelope glycoprotein (Env) typically take years to develop. Longitudinal analyses of both neutralizing antibody lineages and viruses at serial time points during infection provide a basis for understanding the co-evolutionary contest between HIV and the humoral immune system. Here, we describe the structural characterization of an apex-targeting antibody lineage and autologous clade A viral Env from a donor in the Protocol C cohort… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

  • Protein science : a publication of the Protein Society
  • 2018
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