Co-encapsulation of paclitaxel and C6 ceramide in tributyrin-containing nanocarriers improve co-localization in the skin and potentiate cytotoxic effects in 2D and 3D models.

@article{Carvalho2017CoencapsulationOP,
  title={Co-encapsulation of paclitaxel and C6 ceramide in tributyrin-containing nanocarriers improve co-localization in the skin and potentiate cytotoxic effects in 2D and 3D models.},
  author={Vanessa F M Carvalho and Amanda Migotto and Daniela V Giacone and D{\'e}bora P de Lemos and Thalita Boldrin Zanoni and Silvya Stuchi Maria-Engler and Let{\'i}cia V Costa-Lotufo and Luciana B Lopes},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2017},
  volume={109},
  pages={
          131-143
        }
}
Considering that tumor development is generally multifactorial, therapy with a combination of agents capable of potentiating cytotoxic effects is promising. In this study, we co-encapsulated C6 ceramide (0.35%) and paclitaxel (0.50%) in micro and nanoemulsions containing tributyrin (a butyric acid pro-drug included for potentiation of cytotoxicity), and compared their ability to co-localize the drugs in viable skin layers. The nanoemulsion delivered 2- and 2.4-fold more paclitaxel into viable… CONTINUE READING