Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells.

@article{Ke2014CodeliveryOT,
  title={Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells.},
  author={Xi-Yu Ke and Victor Wee Lin Ng and Shu-jun Gao and Yen Wah Tong and James L. Hedrick and Yi Yan Yang},
  journal={Biomaterials},
  year={2014},
  volume={35 3},
  pages={1096-108}
}
In this study, thioridazine (THZ), which was reported to kill cancer stem cells, was used in a combination therapy with doxorubicin (DOX) to eradicate both cancer cells and DOX-resistant cancer stem cells to mitigate the reoccurrence of the disease. Both THZ and DOX were loaded into micelles with sizes below 100 nm, narrow size distribution and high drug content. The micelles were self-assembled from a mixture of acid-functionalized poly(carbonate) and poly(ethylene glycol) diblock copolymer… CONTINUE READING
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