Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome.

@article{Sun2012CodeliveryOP,
  title={Co-delivery of pEGFP-hTRAIL and paclitaxel to brain glioma mediated by an angiopep-conjugated liposome.},
  author={Xiyang Sun and Zhiqing Pang and Hongxing Ye and Bo Qiu and Liangran Guo and Jingwei Li and Jinfeng Ren and Yong Qian and Qizhi Zhang and Jun Chen and Xinguo Jiang},
  journal={Biomaterials},
  year={2012},
  volume={33 3},
  pages={916-24}
}
In this study, we report an angiopep-2 modified cationic liposome (ANG-CLP) for the efficient co-delivery of a therapeutic gene encoding the human tumour necrosis factor-related apoptosis-inducing ligand (pEGFP-hTRAIL) and paclitaxel (PTX) to glioma. The dual targeting co-delivery system (ANG-CLP/PTX/pEGFP-hTRAIL) improved uptake and gene expression not only in U87 MG cells and BCECs, but also in the glioma bed and infiltrating margin of intracranial U87 MG glioma-bearing models. The system… CONTINUE READING

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