Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy.

  title={Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy.},
  author={Xiaoyuan Yang and Yujia Tang and Meng Wang and Yixuan Wang and Wenxiu Wang and Meilu Pang and Yue-hong Xu},
  journal={International journal of pharmaceutics},
Psoriasis is an immune-mediated skin disorder that affects populations worldwide. Methotrexate (MTX) is a cytotoxic drug with powerful anti-proliferative and anti- inflammatory effects that has gained prominence in treating inflammatory diseases including psoriasis. However, low solubility and side effects through oral administration hinder its systemic application. In this study, we developed a novel niosomes based on ceramide (cerosomes) to co-deliver MTX and nicotinamide (NIC), i.e., MTX/NIC… 
2 Citations
Methotrexate-based ionic liquid as a potent anticancer drug for oral delivery: In vivo pharmacokinetics, biodistribution, and antitumor efficacy.
In vivo antitumor studies demonstrated that IL[ProEt][MTX] suppressed tumor growth more than MTX sodium, suggesting that MTX-based ILs provide a simple scalable approach to improving the oral bioavailability of poorly soluble MTX.
Ethyl Cellulose and Hydroxypropyl Methyl Cellulose Blended Methotrexate-Loaded Transdermal Patches: In Vitro and Ex Vivo
It was concluded from the present study that methotrexate-loaded transdermal patches with EC and HPMC as polymers at different concentrations suit TDDSs ideally and improve patient compliance for the local management of psoriasis.


Hyaluronic Acid Dissolving Microneedle Patch Loaded with Methotrexate for Improved Treatment of Psoriasis.
  • H. Du, Pei Liu, +5 authors Juan Tao
  • Materials Science, Medicine
    ACS applied materials & interfaces
  • 2019
It was found the MTX-loaded dissolving microneedle (MN) patch not only showed well-maintained inhibitory effect in vitro but also alleviated the psoriasis-like skin inflammation in mice and were significantly more efficacious than taking the same dose of drug orally.
Loading of water-insoluble celastrol into niosome hydrogels for improved topical permeation and anti-psoriasis activity.
In conclusion, encapsulation of celastrol by niosomes increased the water-solubility and permeation of Celastrol into the skin, significantly improving its anti-psoriasis activity in mice.
Effects of topical methotrexate loaded gold nanoparticle in cutaneous inflammatory mouse model.
Topical AuNPs-3MPS@MTX treatment is able to induce a reduction of keratinocytes hyperproliferation, epidermal thickness and also inflammatory infiltrate in vivo on imiquimod-induced psoriasis like mice model.
Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: application of Box-Behnken design, in-vitro evaluation and in-vivo skin deposition study.
The results showed that targeted MTX delivery might be achieved using topically applied niosomes for enhanced treatment of psoriasis.
Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models.
The AG-loaded non-ionic surfactant vesicles showed no toxicity, good skin tolerability and were able to improve the drug anti- inflammatory activity in mice, and an improvement of the anti-inflammatory activity of the niosome delivered drug was observed on chemically induced skin erythema in humans.
Methotrexate loaded lipid nanoparticles for topical management of skin-related diseases: Design, characterization and skin permeation potential.
It is demonstrated that lipid nanocarriers constitute a suitable approach for application of methotrexate in skin-related diseases topical therapy and their potential for topical drug delivery is investigated.
Microemulsions mediated effective delivery of methotrexate hydrogel: more than a tour de force in psoriasis therapeutics
Developed MEs-based hydrogel has shown promising results in achieving effective delivery of MTX and has shown its potential in locating the drug at the desired domain of stratum corneum, epidermal and dermal layers of skin and reducing systemic absorption.
Amelioration of imiquimod-induced psoriasis-like dermatitis in mice by DSW therapy inspired hydrogel
The results obtained from in vivo tests indicate that these hydrogels could alleviate the symptoms of psoriasis caused by Imiquimod in mice by reducing the inflammatory factor in STAT3 pathway and therefore reduce the immune stimulation of the spleen.
Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vivo assessment
The overall findings of this study verified the effectiveness of utilizing PEGylated cerosomes to augment the activity of FTN as a topical antifungal agent.
Novel Therapies for Psoriasis
Three systemic medications currently are approved worldwide for the treatment of moderate to severe forms of psoriasis, namely cyclosporine, methotrexate and acitretin, and the need for more specific systemic therapy, targeting the T lymphocyte is now well known.