Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy.

@article{Yang2021CodeliveryOM,
  title={Co-delivery of methotrexate and nicotinamide by cerosomes for topical psoriasis treatment with enhanced efficacy.},
  author={Xiaoyuan Yang and Yujia Tang and Meng Wang and Yixuan Wang and Wenxiu Wang and Meilu Pang and Yue-hong Xu},
  journal={International journal of pharmaceutics},
  year={2021},
  pages={
          120826
        }
}
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9 Citations
Highly Influential Citations
3
Background Citations
4
Methods Citations
1
Results Citations
1

9 Citations

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CCID_A_380218 2253..2274

  • 2022

The Anti-Psoriatic Efficacy and Safety Profile of Topical and Intralesional Methotrexate: A Literature Review

The overall safety profile of the topical forms of MTX was favourable and randomized controlled trials that establish the most effective MTX-delivery system are needed to improve the standard of care for patients with psoriasis.

Methotrexate-based ionic liquid as a potent anticancer drug for oral delivery: In vivo pharmacokinetics, biodistribution, and antitumor efficacy.

References

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  • Biology, Materials Science
    ACS applied materials & interfaces
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It was found the MTX-loaded dissolving microneedle (MN) patch not only showed well-maintained inhibitory effect in vitro but also alleviated the psoriasis-like skin inflammation in mice and were significantly more efficacious than taking the same dose of drug orally.

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Three systemic medications currently are approved worldwide for the treatment of moderate to severe forms of psoriasis, namely cyclosporine, methotrexate and acitretin, and the need for more specific systemic therapy, targeting the T lymphocyte is now well known.

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