Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs.

@article{Jeon2012CodeliveryOS,
  title={Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs.},
  author={Su Yeon Jeon and Ji Sun Park and Han Na Yang and Dae Gyun Woo and Keun-Hong Park},
  journal={Biomaterials},
  year={2012},
  volume={33 17},
  pages={4413-23}
}
Some genes expressed in stem cells interrupt and/or enhance differentiation. Therefore, the aim of this study was to inhibit the expression of unnecessary genes and enhance the expression of specific genes involved in stem cell differentiation by using small interfering RNA (siRNA) and plasmid DNA (pDNA) incorporated into cationic polymers as co-delivery factors. To achieve co-delivery of siRNA and pDNA to human mesenchymal stem cells (hMSCs), two different genes were complexed with poly… CONTINUE READING
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