Co-chaperone FKBP38 promotes HERG trafficking.

  title={Co-chaperone FKBP38 promotes HERG trafficking.},
  author={Valerie E Walker and Roxana Atanasiu and Hung Lam and Alvin Shrier},
  journal={The Journal of biological chemistry},
  volume={282 32},
The Long QT Syndrome is a cardiac disorder associated with ventricular arrhythmias that can lead to syncope and sudden death. One prominent form of the Long QT syndrome has been linked to mutations in the HERG gene (KCNH2) that encodes the voltage-dependent delayed rectifier potassium channel (I(Kr)). In order to search for HERG-interacting proteins important for HERG maturation and trafficking, we conducted a proteomics screen using myc-tagged HERG transfected into cardiac (HL-1) and non… CONTINUE READING