Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes

@inproceedings{Schwalie2013CobindingBY,
  title={Co-binding by YY1 identifies the transcriptionally active, highly conserved set of CTCF-bound regions in primate genomes},
  author={Petra C. Schwalie and Michelle C Ward and Carolyn E. Cain and Andre J. Faure and Yoav Gilad and Duncan T. Odom and Paul Flicek},
  booktitle={Genome Biology},
  year={2013}
}
The genomic binding of CTCF is highly conserved across mammals, but the mechanisms that underlie its stability are poorly understood. One transcription factor known to functionally interact with CTCF in the context of X-chromosome inactivation is the ubiquitously expressed YY1. Because combinatorial transcription factor binding can contribute to the evolutionary stabilization of regulatory regions, we tested whether YY1 and CTCF co-binding could in part account for conservation of CTCF binding… CONTINUE READING
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