Corpus ID: 8341884

Co-amorphous drug systems of carbamazepine: intrinsic dissolution rate improvements

  title={Co-amorphous drug systems of carbamazepine: intrinsic dissolution rate improvements},
  author={Kofi Asare-Addo and Adeola O. Adebisi and Muhammad Usman Ghori},
Co-amorphous systems is one of the attractive strategies used to enhance the dissolution rates of poorly soluble drugs. This strategy has an additional advantage as it has the ability to overcome stability issues that may arise from the conversion of a crystalline drug into its amorphous form. In this study, quench cooling was used to prepare co-amorphous forms of carbamazepine (CBZ) with saccharin (SAC), lactose (LAC) and gluconolactone (GLU) as carriers. Analytical techniques such as P-XRD… Expand

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