Corpus ID: 8341884

Co-amorphous drug systems of carbamazepine: intrinsic dissolution rate improvements

@inproceedings{AsareAddo2017CoamorphousDS,
  title={Co-amorphous drug systems of carbamazepine: intrinsic dissolution rate improvements},
  author={Kofi Asare-Addo and Adeola O. Adebisi and Muhammad Usman Ghori},
  year={2017}
}
Co-amorphous systems is one of the attractive strategies used to enhance the dissolution rates of poorly soluble drugs. This strategy has an additional advantage as it has the ability to overcome stability issues that may arise from the conversion of a crystalline drug into its amorphous form. In this study, quench cooling was used to prepare co-amorphous forms of carbamazepine (CBZ) with saccharin (SAC), lactose (LAC) and gluconolactone (GLU) as carriers. Analytical techniques such as P-XRD… Expand

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References

SHOWING 1-10 OF 38 REFERENCES
Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen.
TLDR
A coamorphous drug/drug combination between the two nonsteroidal anti-inflammatory drugs, naproxen and γ-indomethacin, was prepared and investigated and it was suggested that the two drugs formed a heterodimer. Expand
Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical activation.
TLDR
No recrystallization of either drug in the 1:1 co-milled sample was observed during dissolution testing, with naproxen and cimetidine having a four and two times higher intrinsic dissolution rate, respectively, compared to their crystalline counterparts. Expand
Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancement.
TLDR
Amino acids appear as promising excipients to solve challenges connected with the stability and dissolution of amorphous drugs. Expand
Dissolution and solid state behaviours of carbamazepine-gluconolactone solid dispersion powders: The potential use of gluconolactone as dissolution enhancer
Solid dispersions are one of the most effective methods for improving the dissolution rate of poorly water-soluble drugs; however, this is reliant on the selection of a suitable carrier and solvent.Expand
A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin.
TLDR
In this study, the co-amorphous drug mixture containing naproxen (NAP) and indomethacin (IND) was investigated using infrared spectroscopy (IR) and quantum mechanical calculations and it could be shown that both drugs exist as homodimers in their respective individual amorphous form. Expand
To enhance dissolution rate of poorly water-soluble drugs: glucosamine hydrochloride as a potential carrier in solid dispersion formulations.
TLDR
It has been shown that the use of G-HCl in solid dispersion formulations can significantly enhance the dissolution rate of poorly water-soluble drugs such as carbamazepine. Expand
Solubility Advantage of Amorphous Drugs and Pharmaceutical Cocrystals
The current phase of drug development is witnessing an oncoming crisis due to the combined effects of increasing R&D costs, decreasing number of new drug molecules being launched, several blockbusterExpand
Glucosamine HCl as a new carrier for improved dissolution behaviour: effect of grinding.
TLDR
An attempt to use d-glucosamine HCl (G-HCl) as a potential excipient to improve dissolution rate of carbamazepine (CBZ) from physical mixtures and co-grinding formulations showed that the presence of glucosamine can increase dissolved rate of CBZ compared to pure CBZ. Expand
Improvement of oral bioavailability of carbamazepine by inclusion in 2-hydroxypropyl-β-cyclodextrin
Abstract The purpose of this study was to enhance the solubility and bioavailability of carbamazepine (CBZ) through complexation with 2-hydroxypropyl β-cyclodextrin (HPβCD). CBZ is a poorly waterExpand
Amino acids as co-amorphous stabilizers for poorly water-soluble drugs--Part 2: molecular interactions.
TLDR
The potential of amino acids as small molecular weight excipients in co-amorphous formulations to stabilize the amorphous form of a poorly water-soluble drug through strong and specific molecular interactions with the drug is shown. Expand
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