Co-amorphous Formation Induced by Combination of Tranilast and Diphenhydramine Hydrochloride.

@article{Ueda2017CoamorphousFI,
  title={Co-amorphous Formation Induced by Combination of Tranilast and Diphenhydramine Hydrochloride.},
  author={Hiroshi Ueda and Kazunori Kadota and Masaaki Imono and Takuya Ito and Ayaka Kunita and Yuichi Tozuka},
  journal={Journal of pharmaceutical sciences},
  year={2017},
  volume={106 1},
  pages={123-128}
}
In this study, we investigated the formation of a co-amorphous system of tranilast (TRL) and diphenhydramine hydrochloride (DPH), which are drugs used for treating allergies and inflammation. The crystallization from undercooled melts of the drugs and drug mixtures was evaluated by thermal analysis. Both drugs in the amorphous state underwent crystallization on heating, although the mixture remained in the amorphous state, indicating the formation of a co-amorphous system. The physicochemical… CONTINUE READING

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