Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.

@article{Playford2001CoadministrationOT,
  title={Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.},
  author={Raymond John Playford and Christine E. Macdonald and D P Calnan and David N. Floyd and Theo Podas and William Johnson and Anthony C.B. Wicks and Osman Bashir and Tania Marchbank},
  journal={Clinical science},
  year={2001},
  volume={100 6},
  pages={
          627-33
        }
}
Non-steroidal anti-inflammatory drugs (NSAIDs) are effective analgesics but cause gastrointestinal injury. Present prophylactic measures are suboptimal and novel therapies are required. Bovine colostrum is a cheap, readily available source of growth factors, which reduces gastrointestinal injury in rats and mice. We therefore examined whether spray-dried, defatted colostrum could reduce the rise in gut permeability (a non-invasive marker of intestinal injury) caused by NSAIDs in volunteers and… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Bovine colostrum is a health food supplement which prevents NSAID induced gut damage
TLDR
Bovine colostrum could provide a novel, inexpensive approach for the prevention and treatment of the injurious effects of NSAIDs on the gut and may also be of value for the treatment of other ulcerative conditions of the bowel. Expand
Effect of non-steroidal anti-inflammatory drugs and prostaglandins on the permeability of the human small intestine.
TLDR
The studies show that non-steroidal anti-inflammatory drugs disrupt the intestinal barrier function in man and suggest that the morphological correlates of the damage may reside at the level of the intercellular junctions. Expand
Intestinal permeability and inflammation in patients on NSAIDs
TLDR
Intestinal permeability test dose composition is an important factor when assessing the effects of NSAIDs on intestinal integrity and all the conventional NSAIDs studied were equally associated with small intestinal inflammation apart from aspirin and nabumetone which seem to spare the small bowel. Expand
The pathogenesis and consequence of non steroidal anti-inflammatory drug induced small intestinal inflammation in man.
TLDR
It is proposed that altered intestinal permeability allows the mucosa to be exposed to bacterial degradation products or other toxins and together with reduced chemotaxic response and altered neutrophil function due to NSAID's, this series of events leads to bacterial invasion of the mucosal which is evident by the techniques of 111Indium leucocyte scans and faecal collections. Expand
Non-steroidal anti-inflammatory drugs: how do they damage the gut?
TLDR
This review will highlight the epidemiology of NSAID-induced gastrointestinal toxicity, their effects on prostaglandins, and the phenomenon of cytoprotection, as well as the effects of NSAIDs on the small intestine and colon. Expand
BLOOD AND PROTEIN LOSS VIA SMALL-INTESTINAL INFLAMMATION INDUCED BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS
TLDR
These studies show that small intestinal inflammation caused by NSAIDs is associated with blood and protein loss, both of which may contribute to the general ill-health of rheumatic patients. Expand
Intestinal permeability after single dose gluten challenge in coeliac disease.
TLDR
In view of the modification of the three biopsies diagnostic protocol, permeability tests associated with single gluten challenges may be an added contribution to the accuracy of the diagnosis in childhood. Expand
Mucosal adaptation to aspirin induced gastric damage in humans. Studies on blood flow, gastric mucosal growth, and neutrophil activation.
TLDR
It is concluded that the treatment with aspirin in humans induces gastric adaptation to this agent, which entails the increase in mucosal blood flow, the rise in neutrophil activation, and the enhancement of mucosal growth. Expand
Nonsteroidal antiinflammatory drug-induced intestinal inflammation in humans.
TLDR
It appears that nonsteroidal antiinflammatory drugs cause small intestinal inflammation in two-thirds of patients on long-term treatment and on discontinuation, the inflammation may persist for up to 16 mo. Expand
Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indomethacin-induced gastric damage in the rat.
TLDR
It is concluded that combination therapy of epidermal growth factor with intestinal trefoil factor could provide a more potent, safer approach to the treatment of human gastrointestinal ulceration. Expand
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