Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, Th1/Th2/Tregs cytokines and down-regulation of fibrogenesis in mice with Mesocestoides vogae (Cestoda) infection.

@article{Hrkov2020CoadministrationOS,
  title={Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, Th1/Th2/Tregs cytokines and down-regulation of fibrogenesis in mice with Mesocestoides vogae (Cestoda) infection.},
  author={G. Hr{\vc}kov{\'a} and T. Kuba{\vs}kov{\'a} and K. Reiterov{\'a} and D. Biedermann},
  journal={Experimental parasitology},
  year={2020},
  pages={
          107888
        }
}
  • G. Hrčková, T. Kubašková, +1 author D. Biedermann
  • Published 2020
  • Biology, Medicine
  • Experimental parasitology
  • Silymarin (SIL) represents a natural mixture of polyphenols showing an array of health benefits. The present study, carried out on a model cestode infection induced by Mesocestoides vogae tetrathyridia in the ICR strain of mice, was aimed at investigating the impact of SIL as adjunct therapy on the activity of praziquantel (PZQ) in relation to parasite burden, immunity and liver fibrosis within 20 days post-therapy. In comparison with PZQ alone, co-administration of SIL and PZQ stimulated… CONTINUE READING
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