Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, Th1/Th2/Tregs cytokines and down-regulation of fibrogenesis in mice with Mesocestoides vogae (Cestoda) infection.

@article{Hrkov2020CoadministrationOS,
  title={Co-administration of silymarin elevates the therapeutic effect of praziquantel through modulation of specific antibody profiles, Th1/Th2/Tregs cytokines and down-regulation of fibrogenesis in mice with Mesocestoides vogae (Cestoda) infection.},
  author={Gabriela Hr{\vc}kov{\'a} and Ter{\'e}zia Ma{\vc}{\'a}k Kuba{\vs}kov{\'a} and Katar{\'i}na Reiterov{\'a} and David Biedermann},
  journal={Experimental parasitology},
  year={2020},
  pages={
          107888
        }
}
Antiparasitic Effects of Selected Isoflavones on Flatworms
TLDR
This review suggests that examined flavonoids and their derivates are promising molecules for antiparasitic drug research, due to lack of toxicity, isoflavons could be used directly for therapy, or as adjuvant therapy for diseases caused by medically important cestodes and trematodes.
Serotonin Signalling in Flatworms: An Immunocytochemical Localisation of 5-HT7 Type of Serotonin Receptors in Opisthorchis felineus and Hymenolepis diminuta
TLDR
It is suggested that the muscular structures of flatworms are deeply supplied by 5-HT7-IR elements, which can mediate the serotonin action in the investigated species and is an important component of the flatworm motor control system.
A single‐step synthesis of 1,3,4, 6‐tetraaryl ‐5‐aryliminopiperazin‐2‐one
We report here novel reaction that we found unprecedented, up to our knowledge. In a single step, we obtained unusual result. After magnificent efforts we could deduce the structure. We confirmed the

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Impact of treatment with praziquantel, silymarin and/or β-glucan on pathophysiological markers of liver damage and fibrosis in mice infected with Mesocestoides vogae (Cestoda) tetrathyridia
TLDR
Combined treatment of PZQ with silymarin and/or β-glucan was able to ameliorate or suppress fibrogenesis in the liver, protect liver cells from oxidative damage and, possibly, stimulate regeneration of the parenchyma.
Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice.
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Immunity and immune modulation elicited by the larval cestode Mesocestoides vogae and its products
TLDR
The use of the M. vogae as a cestode infection model and its ES products as a valuable tool for the identification of new therapeutic targets for the control of larval cestodiasis is highlighted.
In vivo effects of anticytokine antibodies on isotype restriction in Mesocestoides corti-infected BALB/c mice
TLDR
The effects of cytokines on parasite-induced isotype expression and the potential for IL-4-independent mechanisms of IgG1 production are discussed.
Cytokine patterns in experimental schistosomiasis mansoni infected mice treated with silymarin
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Treatment with silymarin combined with PZQ in murine schistosomiasis could reduce hepatic fibrosis by their action on the production of pro-inflammatory cytokines.
The effects of tumour necrosis factor on host—parasite relations in murine Mesocestoides corti (Cestoda) infection
TLDR
Investigation of murine infection with tetrathyridia of Mesocestoides corti suggested that impaired macrophage effector function, previously attributed to endogenous endotoxin, which gains access to peritoneal macrophages through an inability of the liver to detoxify endot toxin, may be mediated through TNFα.
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This review critically surveys the literature published mainly within this millennium on the new and emerging applications of silybin (pure, chemically defined substance) and silymarin (flavonoid
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TLDR
Silymarin is a well tolerated and effective antidote for use in hepatotoxicity produced by a number of toxins, including A. phalloides, ethanol and psychotropic drugs.
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