Co-administration of either a selective D1 or D2 dopamine antagonist with methamphetamine prevents methamphetamine-induced behavioral sensitization and neurochemical change, studied by in vivo intracerebral dialysis.

@article{Hamamura1991CoadministrationOE,
  title={Co-administration of either a selective D1 or D2 dopamine antagonist with methamphetamine prevents methamphetamine-induced behavioral sensitization and neurochemical change, studied by in vivo intracerebral dialysis.},
  author={Takashi Hamamura and Kazufumi Akiyama and Kimihiko Akimoto and Kenichi Kashihara and Ken Okumura and Hiroshi Ujike and Saburo Otsuki},
  journal={Brain research},
  year={1991},
  volume={546 1},
  pages={40-6}
}
Repeated administration of amphetamine or methamphetamine (MAP) causes behavioral sensitization in animals. Recently, several studies have revealed that in vivo release of dopamine from presynaptic nerve terminals of mesotelencephalic dopamine neurons is enhanced when sensitized animals are rechallenged with a psychostimulant. The present study investigated the effect of co-administration of SCH 23390 (a selective D1 dopamine receptor antagonist) or YM-09151-2 (a selective D2 dopamine receptor… CONTINUE READING
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