Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy

@inproceedings{OReilly2014CoactingGN,
  title={Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy},
  author={Paul O’Reilly and Csaba P. Ortutay and Grainne Gernon and E. E. O’Connell and Cathal Seoighe and Susan Boyce and Luis J Serrano and Eva Szegezdi},
  booktitle={BMC Genomics},
  year={2014}
}
Identification of differentially expressed genes from transcriptomic studies is one of the most common mechanisms to identify tumor biomarkers. This approach however is not well suited to identify interaction between genes whose protein products potentially influence each other, which limits its power to identify molecular wiring of tumour cells dictating response to a drug. Due to the fact that signal transduction pathways are not linear and highly interlinked, the biological response they… CONTINUE READING

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