Co-Evolution of Transcriptional Silencing Proteins and the DNA Elements Specifying Their Assembly

Abstract

Co-evolution of transcriptional regulatory proteins and their sites of action has been often hypothesized but rarely demonstrated. Here we provide experimental evidence of such co-evolution in yeast silent chromatin, a finding that emerged from studies of hybrids formed between two closely related Saccharomyces species. A unidirectional silencing… (More)
DOI: 10.1371/journal.pbio.1000550

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