Co-Delivery of Teriflunomide and Methotrexate from Hydroxyapatite Nanoparticles for the Treatment of Rheumatoid Arthritis: In Vitro Characterization, Pharmacodynamic and Biochemical Investigations

@article{Pandey2018CoDeliveryOT,
  title={Co-Delivery of Teriflunomide and Methotrexate from Hydroxyapatite Nanoparticles for the Treatment of Rheumatoid Arthritis: In Vitro Characterization, Pharmacodynamic and Biochemical Investigations},
  author={Shweta Pandey and Vijay Bhooshan Kumar and Ankita Leekha and N Sathvik Rai and Farhan Jalees Ahmad and Anita Kamra Verma and Sushama Talegaonkar},
  journal={Pharmaceutical Research},
  year={2018},
  volume={35},
  pages={1-17}
}
AbstractPurposeThe present investigation was aimed at developing Teriflunomide (TEF) and Methotrexate (MTX) loaded hydroxyapatite nanoparticles and increasing tolerability towards combination therapy against rheumatoid arthritis by reducing hepatotoxicity.MethodsDrug-loaded HAp-NPs were synthesized by wet-chemical precipitation method and optimized by Box-Behnken experimental design. The developed NPs were subjected to in vitro and in vivo characterization. In-vivo pharmacodynamics and… CONTINUE READING
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