Co-Conserved Features Associated with cis Regulation of ErbB Tyrosine Kinases

Abstract

BACKGROUND The epidermal growth factor receptor kinases, or ErbB kinases, belong to a large sub-group of receptor tyrosine kinases (RTKs), which share a conserved catalytic core. The catalytic core of ErbB kinases have functionally diverged from other RTKs in that they are activated by a unique allosteric mechanism that involves specific interactions… (More)
DOI: 10.1371/journal.pone.0014310

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