• Medicine
  • Published in
    International journal of…
    2014

Co-Administration of Silymarin and Deferoxamine against Kidney, Liver and Heart Iron Deposition in Male Iron Overload Rat Model

@inproceedings{NavidiShishaone2014CoAdministrationOS,
  title={Co-Administration of Silymarin and Deferoxamine against Kidney, Liver and Heart Iron Deposition in Male Iron Overload Rat Model},
  author={Mitra Navidi-Shishaone and Soheila Mohhebi and Mehdi Nematbakhsh and Shahla Roozbehani and Ardeshir Talebi and Zahra Pezeshki and Fatemeh Eshraghi-Jazi and Safoora Mazaheri and Sohiela Shirdavani and Marjan Gharagozloo and Behjat Alsaadat Moaeidi},
  booktitle={International journal of preventive medicine},
  year={2014}
}
BACKGROUND Tissue iron deposition may disturb functions of the organs. In many diseases like thalassemia, the patients suffer from iron deposition in kidney and heart tissues. Deferoxamine (DF) is a synthetic iron chelator and silymarin (SM) is an antioxidant and also a candidate for iron chelating. This study was designed to investigate the effect of DF and SM combination against kidney and heart iron deposition in an iron overload rat model. METHODS Male Wistar rats were randomly assigned… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

Comparison of the prophylactic effect of silymarin and deferoxamine on iron overload‐induced hepatotoxicity in rat

H Najafzadeh, MR Jalali, H Morovvati, F. Taravati
  • J Med Toxicol 2010;6:22‐6
  • 2014
VIEW 1 EXCERPT

Assessment of cardiac iron deposition in sickle cell disease using 3.0 Tesla cardiovascular magnetic resonance

Ibrahim el-SH, FN Rana, KR Johnson, RD White
  • Hemoglobin
  • 2012
VIEW 1 EXCERPT

Iron-induced cardiac damage: role of apoptosis and deferasirox intervention.

Yeling Wang, Miaozong Wu, +9 authors Eric Blough
  • The Journal of pharmacology and experimental therapeutics
  • 2011
VIEW 1 EXCERPT