Co‐infection of helminths and malaria: modulation of the immune responses to malaria

  title={Co‐infection of helminths and malaria: modulation of the immune responses to malaria},
  author={Franca C. Hartgers and Maria Yazdanbakhsh},
  journal={Parasite Immunology},
Chronic helminth infections induce strong type 2 and regulatory immune responses and are known to influence immune activity to other antigens such as allergens and vaccines. Since malaria and helminth infections often coincide geographically in the same tropical regions, the question arises whether helminth infections modulate the immune responses towards the malaria parasite and affect its course of disease. Here, we will review studies on co‐infections in both animal models and in human… 

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How Helminths Alter Immunity to Infection

  • W. Horsnell
  • Biology, Medicine
    Advances in Experimental Medicine and Biology
  • 2014
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Sponsored document from Microbes and Infection / Institut Pasteur

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Long-lived parasites such as the helminths are more remarkable for their ability to downregulate host immunity, protecting themselves from elimination and minimizing severe pathology in the host.

Impairment of Protective Immunity to Blood-Stage Malaria by Concurrent Nematode Infection

It is demonstrated that concurrent nematode infection strongly modulates multiple aspects of immunity to blood-stage malaria and consequently impairs the development of protective antimalarial immunity.

Protective and pathogenic roles of CD8+ T cells during malaria infection

What is known about the development, specificity and protective effect of malaria‐specific CD8+ T cells and report on recent developments in the field are summarized.

Development and regulation of cell-mediated immune responses to the blood stages of malaria: implications for vaccine research.

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Altered Immune Responses in Mice with ConcomitantSchistosoma mansoni and Plasmodium chabaudiInfections

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Malaria-filaria coinfection in mice makes malarial disease more severe unless filarial infection achieves patency.

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Immune effector mechanisms in malaria

Tackling the methodological issues of defining protection and immune response, together with studies that combine functional assays with new approaches such as allelic exchange and gene knock out offer opportunities for better defining key targets and mechanisms.

Epidemiology of helminth infections and their relationship to clinical malaria in southwest Uganda.