Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission

  title={Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission},
  author={Theofanis Karayannis and Eunkyu Au and J. C. Patel and Ilya Kruglikov and Sander Markx and Richard Delorme and D{\'e}lphine Heron and Daniela Salomon and Joseph T. Glessner and Sophie Restituito and Assaf Gordon and Laura Rodr{\'i}guez-Murillo and N. C. Roy and Joseph A Gogos and Bernardo Rudy and M. E. Rice and Maria Karayiorgou and Hakon Hakonarson and Boris Keren and Guillaume Huguet and Thomas Bourgeron and Charles A Hoeffer and R. W. Tsien and Elior Peles and Gordon Fishell},
Although considerable evidence suggests that the chemical synapse is a lynchpin underlying affective disorders, how molecular insults differentially affect specific synaptic connections remains poorly understood. For instance, Neurexin 1a and 2 (NRXN1 and NRXN2) and CNTNAP2 (also known as CASPR2), all members of the neurexin superfamily of transmembrane molecules, have been implicated in neuropsychiatric disorders. However, their loss leads to deficits that have been best characterized with… CONTINUE READING
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