Cntnap4/Caspr4 Differentially Contributes to GABAergic and Dopaminergic Synaptic Transmission

@article{Karayannis2014Cntnap4Caspr4DC,
  title={Cntnap4/Caspr4 Differentially Contributes to GABAergic and Dopaminergic Synaptic Transmission},
  author={T. Karayannis and E. Au and J. Patel and I. Kruglikov and S. Markx and R. Delorme and D. Heron and D. Salomon and J. Glessner and S. Restituito and A. Gordon and L. Rodriguez-Murillo and N. C. Roy and J. Gogos and B. Rudy and M. Rice and M. Karayiorgou and H. Hakonarson and B. Keren and G. Huguet and T. Bourgeron and C. Hoeffer and R. W. Tsien and E. Peles and G. Fishell},
  journal={Nature},
  year={2014},
  volume={511},
  pages={236 - 240}
}
  • T. Karayannis, E. Au, +22 authors G. Fishell
  • Published 2014
  • Biology, Medicine
  • Nature
  • Although considerable evidence suggests that the chemical synapse is a lynchpin underlying affective disorders, how molecular insults differentially affect specific synaptic connections remains poorly understood. For instance, Neurexin 1a and 2 (NRXN1 and NRXN2) and CNTNAP2 (also known as CASPR2), all members of the neurexin superfamily of transmembrane molecules, have been implicated in neuropsychiatric disorders. However, their loss leads to deficits that have been best characterized with… CONTINUE READING
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