Cns effects of choline administration: Evidence for temporal dependence

  title={Cns effects of choline administration: Evidence for temporal dependence},
  author={Dennis E. Schmidt and L. de Wecker},
Abstract The time-course of the prophylactic effects of acute choline administration (60 mg/kg, i.p.) in attenuating atropine-induced depletion of acetylcholine (ACh) in the hippocampus and striatum of rats was studied. The observed effects of choline administration did not coincide with the occurrence of elevated free choline levels in brain. Furthermore, the time course of the effects differed in the 2 brain regions. In the hippocampus, the effects of choline were not evident until 60 min… Expand
Exogenous Choline Enhances the Synthesis of Acetylcholine Only Under Conditions of Increased Cholinergic Neuronal Activity
Results indicate that the acute administration of choline antagonizes pharmacologically induced alterations in cholinergic activity as assessed by the rate of HACU and the steady‐state concentration of ACh, and support the hypothesis that the administration of Choline increases the ability of central cholinerential neurons to synthesize ACh under conditions of increased neuronal activity. Expand
Neurochemical effects of choline supplementation.
  • L. Wecker
  • Chemistry, Medicine
  • Canadian journal of physiology and pharmacology
  • 1986
Although choline supplementation does not alter the levels of ACh in brain under normal conditions, it does appear to support ACh synthesis during drug-induced increases in neuronal activity, an effect most likely mediated by alterations in the metabolism of choline-containing phospholipids. Expand
Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide.
Under stimulated conditions, hippocampal ACh release could be facilitated when the availability of choline for ACh synthesis was enhanced by dietary or pharmacological means, and significant effects of increased choline availability on A Ch release can be revealed in the absence of an overall increase of extracellular choline. Expand
Acetylcholine formation from glucose following acute choline supplementation
The results suggest that shorttern elevation of brain choline does not enhance ACh formation from [U-14C]glucose, and argue against enhanced presynaptic cholinergic function after acute, systemic choline administration. Expand
Glucose enhancement of scopolamine-induced increase of hippocampal high-affinity choline uptake in mice: relation to plasma glucose levels
The hypothesis that glucose administration can facilitate acetylcholine synthesis under certain conditions and that this action could explain how glucose attenuates scopolamine-induced amnesia is supported. Expand
The Utilization of Supplemental Choline by Brain
The disposition and metabolism of choline and its utilization for the synthesis of acetylcholine (ACh) in brain have been the subject of numerous investigations (for reviews see 2, 3, 4, 18).Expand
Interaction of choline and scopolamine in human memory.
Results indicate that any enhancement of cholinergic activity due to increased dietary choline is transient and of small magnitude. Expand
Effects of the Combined Treatment of Rats with Fluphenazine and Choline or Lecithin on the Striatal Cholinergic and Dopaminergic System
It has been reported that the acute administration of choline (Ch) or its dietary precursor, lecithin (phosphatidylcholine; PCh) results in an increase in the steady-state concentration ofExpand
Acute Choline Supplementation In Vivo Enhances Acetylcholine Synthesis In Vitro when Neurotransmitter Release Is Increased by Potassium
Results demonstrate that acute supplementation with choline provides precursor to support acetylcholine synthesis when the release of neurotransmitter is increased. Expand
Influence of Dietary Choline Availability and Neuronal Demand on Acetylcholine Synthesis by Rat Brain
  • L. Wecker
  • Biology, Medicine
  • Journal of neurochemistry
  • 1988
Results indicate that, despite an increased production of free choline by brain slices from choline‐supplemented rats, the synthesis of acetylcholine was unaltered, even in the presence of an increased neuronal demand. Expand


Choline generated from the hydrolysis of acetylcholine may play a significant role in the regulation of neurotransmitter synthesis in the striatum, but not in the other brain areas studied. Expand
Central cholinergic function: relationship to choline administration.
Results suggest that dietary choline is intimately involved with central cholinergic mechanisms, but effects may not be mediated through alterations in neurotransmitter levels. Expand
Effect of high plasma choline on brain area acetylcholine content: drug intervention.
The data suggest that exogenous choline may function as a central direct muscarinic receptor agonist rather than as a precursor of ACh when it increased striatal ACh content. Expand
Choline administration: central effect mediated by stimulation of acetylcholine synthesis.
The results indicate that oral administration of choline augments central cholinergic function, and suggest that the mechanism involves stimulation of the rate of synthesis and release of acetylcholine. Expand
Brain acetylcholine: increase after systemic choline administration.
Observations suggest that precursor availability may influence brain ACh synthesis, just as brain tryptophan and tyrosine levels have previously been shown to control the synthesis of brain serotonin and catecholamines. Expand
The effect of atropine on the turnover of acetylcholine in the mouse brain.
The effect of atropine on the acetylcholine (ACh) turnover in the mouse brain has been studied and related to the central effect (motor activity) of the drug. At the threshold dose for maximalExpand
Regional levels of choline and acetylcholine in rat brain following head focussed microwave sacrifice: Effect of (+)-amphetamine and (±)-parachloroamphetamine
  • D. Schmidt
  • Medicine, Chemistry
  • Neuropharmacology
  • 1976
It is suggested that the short-term change in ACh levels induced by p-chloroamphetamine and amphetamine are mediated via release of dopamine and may indicate that serotonin is involved in the regulation of ACh turnover in the striatum. Expand
Increase in rat brain acetylcholine induced by choline or deanol.
It is found that synthesis of brain acetylcholine can be stimulated in vivo by elevating the tissue concentration of its precursor, indicating that the concentration of free choline in brain is below that necessary for a maximal rate of synthesis of acetyl choline. Expand
The Use of Choline Acetyltransferase as a Cholinergic Marker in the Determination of High‐Affinity Choline Uptake
This paper presents results of some experiments in which CAT activity was used as a basis for calculating the rate of HACU, and the method is used routinely in the laboratory and the results presented here were chosen randomly from a large series of experiments being conducted. Expand
Regulation of Acetylcholine Release During Increased Neuronal Activity
The availability of choline (Ch) in the microenvironment of the nerve terminal and its transport across the neuronal membrane may play a significant role in the dynamic regulation of acetylcholineExpand