Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease.

@article{Vanfleteren2013ClustersOC,
  title={Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease.},
  author={Lowie E.G.W. Vanfleteren and Martijn A. Spruit and Miriam T. J. Groenen and Swetlana Gaffron and Vanessa P.M. van Empel and Piet L. B. Bruijnzeel and Erica P. A. Rutten and Jos op ‘t Roodt and Emiel F. M. Wouters and Frits M. E. Franssen},
  journal={American journal of respiratory and critical care medicine},
  year={2013},
  volume={187 7},
  pages={
          728-35
        }
}
RATIONALE Comorbidities contribute to disease severity and mortality in patients with chronic obstructive pulmonary disease (COPD). Comorbidities have been studied individually and were mostly based on self-reports. The coexistence of objectively identified comorbidities and the role of low-grade systemic inflammation in the pathophysiology of COPD remain to be elucidated. OBJECTIVES To cluster 13 clinically important objectively identified comorbidities, and to characterize the comorbidity… 

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