Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease
@article{Busche2008ClustersOH,
title={Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease},
author={Marc Aurel Busche and Gerhard Eichhoff and Helmuth Adelsberger and Doroth{\'e}e Abramowski and K. -H. Wiederhold and Christian Haass and Matthias Staufenbiel and Arthur Konnerth and Olga Garaschuk},
journal={Science},
year={2008},
volume={321},
pages={1686 - 1689}
}The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo by using two-photon Ca2+ imaging in a mouse model of Alzheimer's disease. Although a decrease in neuronal activity was seen in 29% of layer 2/3 cortical neurons, 21% of neurons displayed an unexpected increase in the frequency of spontaneous Ca2+ transients. These “hyperactive” neurons were found exclusively near the…
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