Clustering of the platelet Fc gamma receptor induces noncovalent association with the tyrosine kinase p72syk.

@article{Chacko1994ClusteringOT,
  title={Clustering of the platelet Fc gamma receptor induces noncovalent association with the tyrosine kinase p72syk.},
  author={G W Chacko and A M Duchemin and K Mark Coggeshall and Jeanne M. Osborne and John Brandt and Clark Anderson},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 51},
  pages={32435-40}
}
The Fc receptor for IgG in platelets was identified as the integral membrane isoform encoded by the Fc gamma RIIA gene. Functional analysis of this molecule determined that activated Fc gamma RIIA is tyrosine phosphorylated and that activation induced the physical association with the protein tyrosine kinase p72syk. Other tyrosine-phosphorylated molecules also co-immunoadsorbed with the activated receptor. Tyrosine kinase activity co-immunoadsorbing with the platelet Fc gamma R was enhanced… CONTINUE READING
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