Clustering of low usage codons and ribosome movement.

  title={Clustering of low usage codons and ribosome movement.},
  author={Shangao Zhang and Emanuel Goldman and Geoffrey Zubay},
  journal={Journal of theoretical biology},
  volume={170 4},
A model is presented in which the distribution of low-usage codons in a message is a major factor in determining the impact that they will have on the translation rate and distribution of ribosomes on that message. This model is based on the assumption that low-usage codons are translated more slowly than normal codons, an assumption supported by various… CONTINUE READING