Clustering of housekeeping genes provides a unified model of gene order in the human genome

  title={Clustering of housekeeping genes provides a unified model of gene order in the human genome},
  author={Martin J. Lercher and Araxi O Urrutia and Laurence D. Hurst},
  journal={Nature Genetics},
It is often supposed that, except for tandem duplicates, genes are randomly distributed throughout the human genome. However, recent analyses suggest that when all the genes expressed in a given tissue (notably placenta and skeletal muscle) are examined, these genes do not map to random locations but instead resolve to clusters. We have asked three questions: (i) is this clustering true for most tissues, or are these the exceptions; (ii) is any clustering simply the result of the expression of… CONTINUE READING
Highly Influential
This paper has highly influenced 22 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 287 extracted citations

PceRBase: a database of plant competing endogenous RNA

Nucleic Acids Research • 2017
View 4 Excerpts
Highly Influenced

Evolutionary origin and maintenance of coexpressed gene clusters in mammals.

Molecular biology and evolution • 2006
View 7 Excerpts
Highly Influenced

Coexpression of linked genes in Mammalian genomes is generally disadvantageous.

Molecular biology and evolution • 2008
View 5 Excerpts
Highly Influenced

Effects of Constitutive Gene Expression on the Dynamics of Random Boolean Networks

2006 IEEE International Conference on Evolutionary Computation • 2006
View 4 Excerpts
Highly Influenced

A benchmark of gene expression tissue-specificity metrics

Briefings in Bioinformatics • 2017
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 13 references

Gene clusters and polycistronic transcription in eukaryotes.

BioEssays : news and reviews in molecular, cellular and developmental biology • 1998

Similar Papers

Loading similar papers…