Clustering of housekeeping genes provides a unified model of gene order in the human genome

@article{Lercher2002ClusteringOH,
  title={Clustering of housekeeping genes provides a unified model of gene order in the human genome},
  author={Martin J. Lercher and Araxi O Urrutia and Laurence D. Hurst},
  journal={Nature Genetics},
  year={2002},
  volume={31},
  pages={180-183}
}
It is often supposed that, except for tandem duplicates, genes are randomly distributed throughout the human genome. However, recent analyses suggest that when all the genes expressed in a given tissue (notably placenta and skeletal muscle) are examined, these genes do not map to random locations but instead resolve to clusters. We have asked three questions: (i) is this clustering true for most tissues, or are these the exceptions; (ii) is any clustering simply the result of the expression of… CONTINUE READING
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