Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma.

@article{Alaminos2004ClusteringOG,
  title={Clustering of gene hypermethylation associated with clinical risk groups in neuroblastoma.},
  author={Miguel Alaminos and Ver{\'o}nica D{\'a}valos and Nai-Kong V Cheung and William L. Gerald and Manel Esteller},
  journal={Journal of the National Cancer Institute},
  year={2004},
  volume={96 16},
  pages={1208-19}
}
BACKGROUND Neuroblastoma is the most common extracranial solid malignancy in infancy and childhood, but the biological factors involved in its development and progression are still unclear. Transcriptional silencing of tumor suppressor genes mediated by hypermethylation of promoter CpG islands is a hallmark of human tumors. We addressed the clinical relevance of promoter hypermethylation in neuroblastoma. METHODS We examined the methylation status of 45 candidate genes representative of many… CONTINUE READING

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