Clustering of cytokine genes on mouse chromosome 11

  title={Clustering of cytokine genes on mouse chromosome 11},
  author={Susan D. Wilson and P R Billings and Peter D'Eustachio and R. E. Keith Fournier and Erhard Geissler and Peter A. Lalley and Parris R. Burd and David Housman and Benjamin A. Taylor and M. E. Dorf},
  journal={The Journal of Experimental Medicine},
  pages={1301 - 1314}
The presence of positionally conserved amino acid residues suggests that the mouse proteins TCA3, P500, MIP1-alpha, MIP1-beta, and JE are members of a single gene family. These proteins are activation specific and can be expressed by both myeloid and lymphoid cells. MIP1-alpha/MIP1-beta and MCAF (the putative human homologue of JE) act as chemotactic and activating agents for neutrophils and macrophages, respectively. The functions of TCA3 and P500 are unknown. We have used interspecies somatic… CONTINUE READING