Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals

  title={Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals},
  author={John Barthelow Classen},
  journal={The Open Pediatric Medicine Journal},
  • J. B. Classen
  • Published 11 February 2008
  • Medicine
  • The Open Pediatric Medicine Journal
Background: Previous studies demonstrated clusters of cases of IDDM occurring 24 to 48 months after immu- nization with the hemophilus, pertussis and combined measles mumps rubella vaccines. Data was analyzed to determine if similar clustering of cases of IDDM occurred after immunization with the hepatitis B vaccine. Methods: Data on the inci- dence of IDDM from hepatitis B immunized and unimmunized cohorts of children was analyzed for the presence of clus- ters occurring after hepatitis B… 
Vaccination and risk of type 1 diabetes mellitus in active component U.S. Military, 2002-2008.
It is recommended that follow-up studies using medical record review to confirm case status should be considered to corroborate these findings and find an increased risk of diagnosed type 1 diabetes and any of the study vaccines.
Health effects in vaccinated versus unvaccinated children, with covariates for breastfeeding status and type of birth
Vaccination is the predominant public health practice utilized by nations to prevent the spread of communicable illnesses. In the United States, fully vaccinated children receive 26 vaccine doses by


Clustering of Cases of Insulin Dependent Diabetes (IDDM) Occurring Three Years After Hemophilus Influenza B (HiB) Immunization Support Causal Relationship Between Immunization and IDDM
Exposure to HiB immunization is associated with an increased risk of IDDM and non-obese diabetic prone mice were immunized with a hemophilus vaccine to determine if immunization increased the risk ofIDDM.
Immunization in the first month of life may explain decline in incidence of IDDM in The Netherlands.
It is proposed that children born in 1962 during an European smallpox epidemic may have received the smallpox vaccine in the first month of life and this may have attributed to the decreased risk of IDDM in these children.
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Three comparable vaccines against hepatitis B, consisting of recombinant HBsAg, are registered in Switzerland and induce seroconversion in 95% of subjects following a 0, 1, 6 or 0,1, 2 and 12 months schedule, allowing a reduction in the number of doses required for protection.
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The French program for immunization has undergone great changes since the last 90', with new vaccines and strategy improvement. The resurgence of pertussis in young adults with transmission to young
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This is the first epidemiologic study to evaluate the possibility that timing of vaccination is related to risk of clinical diabetes in children, and the results are generally in agreement with previous studies in not finding any increased risks.
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Presentation of IAAs is a consistent feature of this autoimmunity, and IAA detection can identify children at risk, and IAAs were detected most frequently.
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The rise in incidence of type I diabetes in France was of the same magnitude as observed in the rest of Europe over 10 y, and a specific pattern was observed in children under 5 y of age, contrasting with stable rates over 15 y.
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Animal toxicology studies indicate that the effect of vaccines on human insulin dependent diabetes needs to be examined and the timing and content of human vaccines can affect the development of diabetes.
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ICAs are emphasized as the primary tool for risk evaluation in siblings followed by restricted HLA subtyping to reduce the population to be subjected to clinical intervention trials.