Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals

  title={Clustering of Cases of IDDM 2 to 4 Years after Hepatitis B Immunization is Consistent with Clustering after Infections and Progression to IDDM in Autoantibody Positive Individuals},
  author={John Barthelow Classen},
  journal={The Open Pediatric Medicine Journal},
  • J. Classen
  • Published 11 February 2008
  • Medicine
  • The Open Pediatric Medicine Journal
Background: Previous studies demonstrated clusters of cases of IDDM occurring 24 to 48 months after immu- nization with the hemophilus, pertussis and combined measles mumps rubella vaccines. Data was analyzed to determine if similar clustering of cases of IDDM occurred after immunization with the hepatitis B vaccine. Methods: Data on the inci- dence of IDDM from hepatitis B immunized and unimmunized cohorts of children was analyzed for the presence of clus- ters occurring after hepatitis B… 

Tables from this paper

Health effects in vaccinated versus unvaccinated children, with covariates for breastfeeding status and type of birth

Vaccination is the predominant public health practice utilized by nations to prevent the spread of communicable illnesses. In the United States, fully vaccinated children receive 26 vaccine doses by



Mumps infections in the etiology of type 1 (insulin-dependent) diabetes.

The results confirm several earlier reports suggesting a connection between mumps and Type 1 diabetes and that the onset of diabetes may be delayed by several years.

[Vaccination calendar and new risks of infection].

The French program for immunization has undergone great changes since the last 90', with new vaccines and strategy improvement. The resurgence of pertussis in young adults with transmission to young

Childhood vaccinations, vaccination timing, and risk of type 1 diabetes mellitus.

This is the first epidemiologic study to evaluate the possibility that timing of vaccination is related to risk of clinical diabetes in children, and the results are generally in agreement with previous studies in not finding any increased risks.

Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study.

Presentation of IAAs is a consistent feature of this autoimmunity, and IAA detection can identify children at risk, and IAAs were detected most frequently.

Incidence Data of Childhood-Onset Type I Diabetes in France During 1988–1997: The Case for a Shift Toward Younger Age at Onset

The rise in incidence of type I diabetes in France was of the same magnitude as observed in the rest of Europe over 10 y, and a specific pattern was observed in children under 5 y of age, contrasting with stable rates over 15 y.

The timing of immunization affects the development of diabetes in rodents.

Animal toxicology studies indicate that the effect of vaccines on human insulin dependent diabetes needs to be examined and the timing and content of human vaccines can affect the development of diabetes.

Islet cell autoimmunity and progression to insulin‐dependent diabetes mellitus in genetically high‐ and low‐risk siblings of diabetic children

ICAs are emphasized as the primary tool for risk evaluation in siblings followed by restricted HLA subtyping to reduce the population to be subjected to clinical intervention trials.

A 5-year (1989–1993) Prospective Study of the Incidence of IDDM in Rome and the Lazio Region in the Age-Group 0–14 years

It is concluded that the IDDM incidence rate in Rome and its region is comparable to that in other Southern European countries and remained stable over the 5-year observation period.

Is Diabetes of Infectious Origin

Among the large series of etiological factors ascribed to diabetes mellitus, serious attention has not been paid to its possible infectious origin, inasmuch as diabetes does not bear the stamp of an

Progression to Type I Diabetess in Autoimmune Endocrine Patients With Islet Cell Antibodies

The data confirm the predictive ability of ICAs and lAAs for type I diabetes and indicate that the events that lead to disease in individuals with ICAs are influenced by the level of the humoral response and by a familial association of type Iabetes.