Clustering of Ca2+ transients in interstitial cells of Cajal defines slow wave duration

@inproceedings{Drumm2017ClusteringOC,
  title={Clustering of Ca2+ transients in interstitial cells of Cajal defines slow wave duration},
  author={Bernard T Drumm and Grant W. Hennig and Matthew J. Battersby and Erin K Cunningham and Tae Sik Sung and Sean M Ward and Kenton M. Sanders and Salah A Baker},
  booktitle={The Journal of general physiology},
  year={2017}
}
Interstitial cells of Cajal (ICC) in the myenteric plexus region (ICC-MY) of the small intestine are pacemakers that generate rhythmic depolarizations known as slow waves. Slow waves depend on activation of Ca2+-activated Cl- channels (ANO1) in ICC, propagate actively within networks of ICC-MY, and conduct to smooth muscle cells where they generate action potentials and phasic contractions. Thus, mechanisms of Ca2+ regulation in ICC are fundamental to the motor patterns of the bowel. Here, we… CONTINUE READING
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