Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signalling.

@article{Hara2015ClusteringOC,
  title={Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signalling.},
  author={Hiromitsu Hara and Tadashi Yokosuka and Hideki Hirakawa and Chitose Ishihara and Shinsuke Yasukawa and Masanori Yamazaki and Haruhiko Koseki and Hiroki Yoshida and Takashi K. Saito},
  journal={Nature communications},
  year={2015},
  volume={6},
  pages={
          5555
        }
}
CARMA1-mediated NF-κB activation controls lymphocyte activation through antigen receptors and survival of some malignant lymphomas. CARMA1 clusters are formed on physiological receptor-mediated activation or by its oncogenic mutation in activated B-cell-diffuse large B-cell lymphomas (ABC-DLBCLs) with constitutive NF-κB activation. However, regulatory mechanisms and relevance of CARMA1 clusters in the NF-κB pathway are unclear. Here we show that SH3 and GUK domain interactions of CARMA1 link… CONTINUE READING
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