Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization.

@article{Upla2004ClusteringIA,
  title={Clustering induces a lateral redistribution of alpha 2 beta 1 integrin from membrane rafts to caveolae and subsequent protein kinase C-dependent internalization.},
  author={Paula Upla and Varpu S Marjom{\"a}ki and Pasi Kankaanp{\"a}{\"a} and Johanna Ivaska and Timo Hyypi{\"a} and F Gisou van der Goot and Jyrki Heino},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 2},
  pages={
          625-36
        }
}
Integrin alpha 2 beta 1 mediates the binding of several epithelial and mesenchymal cell types to collagen. The composition of the surrounding plasma membrane, especially caveolin-1- and cholesterol-containing membrane structures called caveolae, may be important to integrin signaling. On cell surface alpha 2 beta 1 integrin was located in the raft like membrane domain, rich in GPI-anchored proteins, rather than in caveolae. However, when antibodies were used to generate clusters of alpha 2 beta… CONTINUE READING