Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin.

@article{Li2004ClusteringAR,
  title={Clustering and redistribution of late endocytic compartments in response to Helicobacter pylori vacuolating toxin.},
  author={Yi Li and Angela Wandinger-Ness and James R Goldenring and Timothy L Cover},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 4},
  pages={
          1946-59
        }
}
Helicobacter pylori VacA is a secreted protein toxin that may contribute to the pathogenesis of peptic ulcer disease and gastric adenocarcinoma. When added to cultured mammalian cells in the presence of weak bases (e.g., ammonium chloride), VacA induces the formation of large cytoplasmic vacuoles. Here, we report a previously unrecognized capacity of VacA to induce clustering and perinuclear redistribution of late endocytic compartments. In contrast to VacA-induced cell vacuolation, VacA… CONTINUE READING

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Redistribution of late endocytic compartments to the perinuclear region requires a functional microtubule cytoskeleton , whereas clustering of these compartments and vacuole formation do not .
Redistribution of late endocytic compartments to the perinuclear region requires a functional microtubule cytoskeleton , whereas clustering of these compartments and vacuole formation do not .
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