Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons.

  title={Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons.},
  author={Chen Gu and Yuanzheng Gu},
  journal={The Journal of biological chemistry},
  volume={286 29},
Precise localization of axonal ion channels is crucial for proper electrical and chemical functions of axons. In myelinated axons, Kv1 (Shaker) voltage-gated potassium (Kv) channels are clustered in the juxtaparanodal regions flanking the node of Ranvier. The clustering can be disrupted by deletion of various proteins in mice, including contactin-associated protein-like 2 (Caspr2) and transient axonal glycoprotein-1 (TAG-1), a glycosylphosphatidylinositol-anchored cell adhesion molecule… CONTINUE READING


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