Clustering Sequences in a Metric Space The MoBIoS Project

Abstract

We are developing a [Molecular] Biological Information System (MoBIoS) based on metric space indices. Unfortunately, common similarity measures for sequence alignment do not form a metric-distance function. This is particularly vexing since the usual definition of edit distance does form a metric. Most clearly, the use of PAM log-odds matrices [2] yields… (More)

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