Clusterin interaction with Bcl-xL is associated with seizure-induced neuronal death.

@article{Kim2012ClusterinIW,
  title={Clusterin interaction with Bcl-xL is associated with seizure-induced neuronal death.},
  author={Yoon Sook Kim and Mee Young Choi and Ji Ho Ryu and Dong Hoon Lee and Byeong Tak Jeon and Gu Seob Roh and Sang Soo Kang and Hyun Joon Kim and Gyeong Jae Cho and Wan Sung Choi},
  journal={Epilepsy research},
  year={2012},
  volume={99 3},
  pages={240-51}
}
Status epilepticus causes significant damage to the brain, and cellular injury due to prolonged seizures may cause the pathogenesis of epilepsy or cognitive deficits. Clusterin mediates several cell signaling pathways, including cell death or survival pathways in the brain. A nuclear form of clusterin protein has been suggested to have pro-apoptotic properties. Bcl-x(L) functions as a dominant-negative modulator of the pro-apoptotic protein Bax. However, the relationship between clusterin and… CONTINUE READING