Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate.

@article{Lakins1998ClusterinBI,
  title={Clusterin biogenesis is altered during apoptosis in the regressing rat ventral prostate.},
  author={Johnathon Lakins and Steffany A L Bennett and Ji Hshiung Chen and J. Malcolm O. Arnold and Colm M Morrissey and Peter Ngai-Sing Wong and Jacintha O'sullivan and Martin Tenniswood},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 43},
  pages={27887-95}
}
Clusterin was first characterized as an apoptosis-associated transcript after it was identified as testosterone-repressed prostate message (TRPM-2) that is expressed in the epithelial cells of the regressing rat ventral prostate. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. However, enhanced protein expression has also been reported in surviving… CONTINUE READING

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