Clusterin as a marker for ischaemic Purkinje cells in human brain.

  title={Clusterin as a marker for ischaemic Purkinje cells in human brain.},
  author={Osamu Yasuhara and Yoshinari Aimi and Tatsuo Yamada and Akinor Matsuo and E. G. McGeer P. L. McGeer and Patrick L. Mcgeer},
  journal={Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration},
  volume={3 4},
Clusterin has been implicated in cell death both in peripheral tissues and in the central nervous system. In the present study, expression of clusterin in the cerebellar cortex was examined in two cases with hypoxic brain damage and in one case with cerebellar infarction. Intense staining of Purkinje cells was observed in each case, and these cells showed the shrunken and pyknotic appearance characteristic of irreversible ischaemic damage. In the cerebella of neurologically normal control cases… CONTINUE READING