Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons

@inproceedings{Robbins2018ClusterinIR,
  title={Clusterin Is Required for β-Amyloid Toxicity in Human iPSC-Derived Neurons},
  author={Jacqueline P. Robbins and Leo William Perfect and Elena M. Ribe and Marcello Maresca and Adri{\`a} Dangla-Valls and Evangeline M. Foster and R Killick and Paulina Nowosiad and Matthew J. Reid and Lucia Dutan Polit and Alejo J. Nevado and Daniel Ebner and Mohammad Bohlooly-Y and Noel J. Buckley and Menelas N. Pangalos and Jack Price and Simon Lovestone},
  booktitle={Front. Neurosci.},
  year={2018}
}
Our understanding of the molecular processes underlying Alzheimer's disease (AD) is still limited, hindering the development of effective treatments, and highlighting the need for human-specific models. Advances in identifying components of the amyloid cascade are progressing, including the role of the protein clusterin in mediating β-amyloid (Aβ) toxicity… CONTINUE READING