Clusterin (SGP-2) induction in rat astroglial cells exposed to prion protein fragment 106-126.

@article{Chiesa1996ClusterinI,
  title={Clusterin (SGP-2) induction in rat astroglial cells exposed to prion protein fragment 106-126.},
  author={Roberto Chiesa and Nadia Angeretti and E. J. De Lucca and Mario Salmona and F. Tagliavini and Orso Bugiani and Gianluigi Forloni},
  journal={The European journal of neuroscience},
  year={1996},
  volume={8 3},
  pages={589-97}
}
Prion-related encephalopathies are characterized by the accumulation of an abnormal prion protein isoform (PrPSc) associated with neuronal degeneration and astrogliosis. The synthetic peptide homologous to PrP fragment 106-126 (PrP 106-126) induced in vitro neuronal apoptosis and glial proliferation. We used Northern blot analysis and the RNA polymerase chain reaction to assess the expression of several genes associated with programmed cell death and proliferation. Blots of total RNA extracted… CONTINUE READING

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