Clustered magnetite nanocrystals cross-linked with PEI for efficient siRNA delivery.

  title={Clustered magnetite nanocrystals cross-linked with PEI for efficient siRNA delivery.},
  author={Ji Won Park and Ki Hyun Bae and Chunsoo Kim and Tae Gwan Park},
  volume={12 2},
Magnetofection has been utilized as a powerful tool to enhance gene transfection efficiency via magnetic field-enforced cellular transport processes. The accelerated accumulation of nucleic acid molecules by applying an external magnetic force enables the rapid and improved transduction efficiency. In this study, we developed magnetite nanocrystal clusters (PMNCs) cross-linked with polyethylenimine (PEI) to magnetically trigger intracellular delivery of small interfering RNA (siRNA). PMNCs were… CONTINUE READING


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