Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins.

@article{DavidCordonnier2000ClusteredDD,
  title={Clustered DNA damage, influence on damage excision by XRS5 nuclear extracts and Escherichia coli Nth and Fpg proteins.},
  author={Marie-H{\'e}l{\`e}ne David-Cordonnier and J. Laval and Peter O'Neill},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 16},
  pages={11865-73}
}
Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damage, which are thought to reflect the biological severity. Escherichia coli Nth and Fpg and nuclear extracts from XRS5, a Chinese hamster ovary Ku-deficient cell line, have been used to study the influence on their substrate recognition by the presence of a neighboring damage or an abasic site on the opposite strand, as models of clustered DNA damage. These proteins were tested for their efficiency to induce a single… CONTINUE READING

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