Clustered CD20 induced apoptosis: src-family kinase, the proximal regulator of tyrosine phosphorylation, calcium influx, and caspase 3-dependent apoptosis.

@article{Hofmeister2000ClusteredCI,
  title={Clustered CD20 induced apoptosis: src-family kinase, the proximal regulator of tyrosine phosphorylation, calcium influx, and caspase 3-dependent apoptosis.},
  author={Joseph K. Hofmeister and D. Paul Cooney and K Mark Coggeshall},
  journal={Blood cells, molecules & diseases},
  year={2000},
  volume={26 2},
  pages={133-43}
}
Anti-CD20 antibodies may reduce or eliminate non-Hodgkin's lymphoma B cells in patients, although the mechanism of action is not clear. To explore mechanism(s), we examined the induction of signal transduction events using anti-CD20 monoclonal antibodies (mAb) in the human non-Hodgkin's lymphoma Ramos B cell line. We found that while Rituximab (a human… CONTINUE READING