Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation.

@article{Pitcher1999ClusterOD,
  title={Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation.},
  author={C Pitcher and Stefan H{\"o}ning and Andy Fingerhut and Katherine Bowers and Mark Marsh},
  journal={Molecular biology of the cell},
  year={1999},
  volume={10 3},
  pages={
          677-91
        }
}
Cluster of differentiation antigen 4 (CD4), the T lymphocyte antigen receptor component and human immunodeficiency virus coreceptor, is down-modulated when cells are activated by antigen or phorbol esters. During down-modulation CD4 dissociates from p56(lck), undergoes endocytosis through clathrin-coated pits, and is then sorted in early endosomes to late endocytic organelles where it is degraded. Previous studies have suggested that phosphorylation and a dileucine sequence are required for… CONTINUE READING

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