Cluster headache is associated with an increased risk of depression: A nationwide population-based cohort study

  title={Cluster headache is associated with an increased risk of depression: A nationwide population-based cohort study},
  author={Jen-Feng Liang and Yung-Tai Chen and Jong-Ling Fuh and Szu-Yuan Li and Chia-Jen Liu and Tzeng-Ji Chen and Chao Hsiun Tang and Shuu-Jiun Wang},
  pages={182 - 189}
Objective To investigate whether cluster headache (CH) was a risk factor for depression in a nationwide population-based follow-up study. Background There are few studies about the relationship between CH and depression, and prior research has been limited by cross-sectional studies or small sample sizes. Methods We identified 673 CH patients from the Taiwan National Health Insurance database between 2005 and 2009. The two comparison cohorts included age-, sex- and Charlson’s score-matched… 

Figures and Tables from this paper

Cluster headache and depression

Current depression is highly prevalent in patients with active disease, in part related to sleep disturbances due to current nocturnal attacks, and is associated with an almost 3 times increased odds of lifetime depression.

Epidemiology of diagnosed cluster headache in Norway

Use of opioid analgesics during the study period was more common among patients with CH compared to others, and increased age and sex adjusted odds ratios were observed for medication-induced headache and suicide attempt.

Sex-related differences in cluster headache: A hospital-based study in Taiwan.

Despite a decline of male-to-female ratio in the past two decades, most clinical profiles were similar between the sexes.

Natural course of untreated cluster headache: A retrospective cohort study

The data suggest that remission of cluster headache might not be a consequence of more advanced age, longer duration of disease, or accumulation of lifetime bouts, as well as a trend for more seasonal and circadian predilection at baseline in the active group.

Risk of Depressive Disorders Following Myasthenia Gravis: A Nationwide Population-Based Retrospective Cohort Study

A retrospective cohort study of patients ageing 20 years and older and also newly diagnosed with MG between January 1, 2000 and December 31, 2008 showed an increased risk in the development of depressive disorders in people with MG.

Hyperalgesia and Central Sensitization Signs in Patients with Cluster Headache: A Cross-Sectional Study.

It is shown that patients with CH have lower PPT levels at cranial and extracranial points, suggesting, as in other primary headaches, the presence of CS, and a high prevalence of psychiatric comorbidities that correlate with the length and frequency of attacks.

The impact of depressive symptoms on the burden of cluster headache: Results of the EUROLIGHT Cluster Headache Project, an Internet-based, cross-sectional study of people with cluster headache

It is possible that fear of pain, self-concealment and fear of impoverishment are consequences of the depression attributed to the headache disorder.

Phenotype of Cluster Headache: Clinical Variability, Persisting Pain Between Attacks, and Comorbidities—An Observational Cohort Study in 825 Patients

The aim of the study was to analyze the severity and extent of the clinical symptoms of episodic and chronic cluster headaches with regard to their variability and to compare them with the requirements of the International Classification of Headache Disorders 3rd edition (ICHD-3) diagnostic criteria.

Temperature variation and the incidence of cluster headache periods: A nationwide population study

This study shows that temperature is associated with precipitating or priming cluster periods, and the influence depends on the temperature of the preceding periods.

Diagnostic Delay and Its Predictors in Cluster Headache

The rate of delayed diagnosis gradually improved over time and with the publication of the ICHD criteria, supporting the clinical significance of diagnostic clinical criteria and headache education to reduce the disease burden of CH.



Factors associated with depression in patients referred to headache specialists

In patients with headache referred for specialist consultation, depression is strongly associated with being on disability or welfare, unemployment, age under 50 years, showing severe headache impact on the Headache Impact Test–6, and receiving a diagnosis of transformed migraine.

Cluster Headache in the Taiwanese — a Clinic-Based Study

Compared to Western series, the authors' patients were different in several aspects including the absence of chronic cluster headaches and a low prevalence of restlessness and aura and racial and geographical factors might contribute to these discrepancies.

The Incidence and Prevalence of Cluster Headache: A Meta-Analysis of Population-Based Studies

A relatively stable lifetime prevalence suggests that about one in 1000 people suffers from cluster headache, the prevalence being independent of the region of the population study.

Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers

Sociodemographic and comorbidity profiles of the CM population differ from the EM population on multiple dimensions, suggesting that CM and EM differ in important ways other than headache frequency.

Chronic cluster headache: a French clinical descriptive study

This study confirms the existence of auras and interictal signs and symptoms in patients with chronic CH, and male sex and smoking as CH risk factors, and primary and secondary chronic CH appear equally prevalent.

Impairment in episodic and chronic cluster headache

Patients with chronic and active episodic CH were severely impaired in non-economic and economic domains such as disability, working life and psychiatric complaints, and psychiatric co-morbidity was highest in chronic CH.

Disability is the Major Determinant of the Severity of Depressive Symptoms in Primary Headaches but not in Low Back Pain

In a multivariate model, determinants of the severity of depressive symptoms were different in headache and non-headache pain subjects, suggesting a different mechanism for developing depression in primary headaches and in other pain syndromes.

Depression in headaches: chronification.

Clinicians are suggested to consider depression as a potential cofactor for migraine chronification in order to optimize treatment and avoid migraine progression.

Migraine and psychiatric comorbidity: a review of clinical findings

This review has mainly considered the findings from general population studies and studies on clinical samples, in adults and children, focusing on the association between migraine and psychiatric disorders (axis I of the DSM), carried over after the first classification of IHS (1988).

Health-Related and Condition-Specific Quality of Life in Episodic Cluster Headache

Although CH patients had lower scores than migraineurs on most scales, the difference was significant only on SF-36 scores measuring bodily pain and social functioning, and there was a good correlation between the two instruments.