Cluster headache

@article{Nesbitt2012ClusterH,
  title={Cluster headache},
  author={A. Nesbitt and P. Goadsby},
  journal={BMJ : British Medical Journal},
  year={2012},
  volume={344}
}
Few, if any, medical disorders are more painful than cluster headache. Previously termed migrainous neuralgia, it was last reviewed in the BMJ nearly 50 years ago. At that time, the authors stressed the importance of covering the topic in a general medical journal to aid recognition. Despite this remarkably prescient view, and the extreme and stereotyped nature of its presentation, cluster headache is still commonly misdiagnosed. Without a clear diagnosis, affected patients can wait many years… Expand
Cluster headache: When to worry? Two case reports
TLDR
The importance of clinical modifications of CH that could suggest clinical investigations should be performed or repeated to exclude a secondary pathology in a previously diagnosed cluster headache is highlighted. Expand
Headache disorders: differentiating and managing the common subtypes
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TLDR
The current pathway of headache care in the UK is discussed with a view to proposing a model that might fit well in the financially constrained National Health Service (NHS) and with new NHS reforms. Expand
All About Cluster Headaches
According to the International Classification of Headache Disorders (ICHD), cluster headaches are a member of the trigeminal autonomic cephalalgia (TAC) family of headaches [1]. Trigeminal refers toExpand
Primary headaches.
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For future research into CSF biomarkers for primary headache disorders, two different strategies should be employed: hypothesis-driven and nonhypothesis-driven biochemical research, to show new avenues for treatment strategies and develop prediction models for clinical use. Expand
Clinical features of cluster headache without cranial autonomic symptoms: results from a prospective multicentre study
TLDR
Among participants with PCH, headache intensity was less severe in participants without CAS than in those with CAS, and some clinical features of CH and PCH differed based on the presence of CAS. Expand
Can Psychedelics Alleviate Symptoms of Cluster Headache and Accompanying Mental Health Problems? A Case Report Involving Hawaiian Baby Woodrose
TLDR
Preliminary evidence supports the efficacy of psychedelics in the alleviation of cluster headache and mental health problems and the first case report to concurrently examine the analgesic and psycho-spiritual effects of Hawaiian baby woodrose is described. Expand
Clinical characteristics of pre-attack symptoms in cluster headache: A large series of Korean patients
  • Soohyun Cho, Soo-Jin Cho, +13 authors Byung-Kun Kim
  • Medicine
  • Cephalalgia : an international journal of headache
  • 2020
TLDR
Pre-attack symptoms were frequently observed in Korean patients with cluster headache, which was consistent with previous Western studies. Expand
Allodynia in cluster headache
TLDR
The high prevalence of cutaneous allodynian with similar risk factors for allodynia as found for migraine suggests that central sensitization, like in migraine, also occurs in cluster headache. Expand
Safety and efficacy of sphenopalatine ganglion stimulation for chronic cluster headache: a double-blind, randomised controlled trial
TLDR
Sphenopalatine ganglion stimulation seems efficacious and is well tolerated, and potentially offers an alternative approach to the treatment of chronic cluster headache. Expand
Efficacy of cabergoline and triptans for cluster-like headache caused by prolactin-secreting pituitary adenoma: A literature review and case report
TLDR
Based on the efficacies of cabergoline and triptans, two different mechanisms may coexist in the pathogenesis of CLHs associated with PA: endocrinological and physical effects of the tumor itself. Expand
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References

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Pathophysiology of cluster headache: a trigeminal autonomic cephalgia
TLDR
Functional neuroimaging with PET and anatomical imaging with voxel-based morphometry have identified the posterior hypothalamic grey matter as the key area for the basic defect in cluster headache. Expand
EFNS guidelines on the treatment of cluster headache and other trigeminal‐autonomic cephalalgias
TLDR
Large series suggest that lamotrigine is the most effective preventive agent, with topiramate and gabapentin also being useful in treatment of SUNCT syndrome, and surgical procedures, although in part promising, require further scientific evaluation. Expand
Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients
TLDR
Improvement occurred within days to weeks for those who responded most and patients consistently reported their attacks returned within hours to days when the device was off and one patient found that ONS helped abort acute attacks. Expand
Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study
TLDR
The delay of 2 months or more between implantation and significant clinical improvement suggests that the procedure acts via slow neuromodulatory processes at the level of upper brain stem or diencephalic centres, and could be safer than deep hypothalamic stimulation. Expand
Hypothalamic activation in cluster headache attacks
TLDR
These findings establish central nervous system dysfunction in the region of the hypothalamus as the primum movens in the pathophysiology of cluster headache and suggest that this type of headache should be regarded as a neurovascular headache. Expand
Neuroimaging in trigeminal autonomic cephalgias: when, how, and of what?
TLDR
A ‘typical’ clinical warning profile for secondary TACs is not identified as patients could present with clinical features that are entirely characteristic of a TAC, including alternating attack and attack-free periods, and excellent response to TAC-specific treatments. Expand
Cranial autonomic symptoms in migraine: characteristics and comparison with cluster headache
TLDR
CAS were present in half of migraine patients and the clinical features may help differentiate migraine from CH, and the prevalence of ⩾1 CAS in migraine patients was 56% and did not differ among migraine subtypes. Expand
Chronic cluster headache: a French clinical descriptive study
TLDR
This study confirms the existence of auras and interictal signs and symptoms in patients with chronic CH, and male sex and smoking as CH risk factors, and primary and secondary chronic CH appear equally prevalent. Expand
Intravenous dihydroergotamine for inpatient management of refractory primary headaches
TLDR
The data suggest that IV dihydroergotamine given over 5 days produces improvement in headache and disability in patients with migraine more than shorter courses, and longer treatments produce a better outcome. Expand
Interictal pain in cluster headache
TLDR
Subjects with persistent interictal pain were more likely to have chronic cluster, allodynia, and suboptimal response to sumatriptan, suggesting that interdictal pain in cluster headache may predict a more severe disease process. Expand
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