Cluster headache: insights from resting-state functional magnetic resonance imaging

  title={Cluster headache: insights from resting-state functional magnetic resonance imaging},
  author={Stefania Ferraro and Anna Paula Nigri and Maria Grazia Bruzzone and Greta Demichelis and Chiara Pinardi and Luca Brivio and Luca Giani and Alberto Proietti and Massimo Leone and Luisa Chiapparini},
  journal={Neurological Sciences},
The comprehension of cluster headache (CH) has greatly benefited from the tremendous progress of the neuroimaging techniques over the last 20 years. Since the pioneering study of May et al. (1998), the neuroimaging results have indeed revolutionized the conception of this disease, now considered as a dysfunction of the central nervous system. Clinical, neuroendocrinological, and neuroimaging studies strongly suggested the involvement of the hypothalamus as the generator of cluster headache… 
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  • S. Joshi
  • Medicine, Psychology
  • 2020
Recent therapeutic advances in the treatment of cluster headache such as monoclonal antibodies as well as non-invasive vagus nerve stimulation are highlighted, and future potential therapeutic targets are examined.
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A novel 12-item screening tool that had a sensitivity and specificity of 86.4% and a specificity of 92.0% in differentiating between CH and migraine could be a useful instrument to aid the diagnosis of a CH.
The impact of remission and coexisting migraine on anxiety and depression in cluster headache
The results indicate that CH patients are at increased risk of anxiety and depression, especially in the presence of coexisting migraine, however, the Anxiety and depression can improve during remission periods.
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Oral administration of zolmitriptan in the preictal period could reduce the severity of headache and shorten the duration of headache in a cluster period without serious adverse reactions.
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In CH patients a diffuse abnormality of brain functional connectivity is present, which extends beyond the antinoceptive system, and is significantly correlated with disease duration.
Altered hypothalamic functional connectivity in cluster headache: a longitudinal resting-state functional MRI study
In CH, FC differences between the hypothalamus and its regional distribution extends beyond traditional pain processing areas, primarily to the cerebellar, frontal and occipital areas.
Abnormal Brain Functional Connectivity of the Hypothalamus in Cluster Headaches
Abnormal brain functional connectivity of the hypothalamus is present in CH, which is located mainly in the pain system during the spontaneous CH attacks, and extends beyond thePain system during CH attack intervals.
Advances in the understanding of cluster headache
Results from ongoing clinical trials in cluster headache sufferers using monoclonal antibodies against CGRP will open soon a new era, and main findings contributing to consider cluster headache as a neurovascular disorder with an origin from within the brain are focused on.
Defective functional connectivity between posterior hypothalamus and regions of the diencephalic-mesencephalic junction in chronic cluster headache
The observed deranged functional connectivity between the posterior ipsilateral hypothalamus and diencephalic-mesencephalic regions in chronic cluster headache patients mainly involves structures that are part of the midbrain dopaminergic systems.
Stimulation of the Posterior Hypothalamus for Treatment of Chronic Intractable Cluster Headaches: First Reported Series
Preliminary results indicate a role for posterior hypothalamic stimulation, which was demonstrated to be safe and effective, in the treatment of drug-resistant chronic CHs, and point to a central pathogenesis for chronicCHs.
Resting‐state functional connectivity of the human hypothalamus
The results indicate that the MH and LH network are tapped into different parts of the dopaminergic circuitry of the brain, potentially modulating food reward based on the functional connections to the ventral and dorsal striatum, respectively.
Ventral tegmental area deep brain stimulation for refractory chronic cluster headache
Evidence is provided that VTA-DBS may be a safe and effective therapy for refractory CCH patients who failed conventional treatments and decreases headache frequency, severity, and headache load in patients with medically intractable chronic cluster headaches.
Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: Experience in five patients with a modified anatomical target
The results supports the efficacy of DBS in very refractory CCH with a slightly modified hypothalamic target conceived to avoid the lateral ventricle wall so as to extend the stimulated brain area and to decrease the morbidity of potential haemorrhagic complications.