Cluster headache: focus on emerging therapies

  title={Cluster headache: focus on emerging therapies},
  author={M. Matharu and P. Goadsby},
  journal={Expert Review of Neurotherapeutics},
  pages={895 - 907}
Cluster headache is a strictly unilateral headache that occurs in association with cranial autonomic features. It is an excruciating syndrome and is probably one of the most painful conditions known to mankind with female patients describing each attack as being worse than childbirth. In most patients, it has a striking circannual and circadian periodicity. This disorder has a highly stereotyped clinical phenotype and responds to specific therapies, thereby underlying the importance of… Expand
Trigeminal autonomic cephalalgias. Part 1: cluster headache.
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Phenotype of Cluster Headache: Clinical Variability, Persisting Pain Between Attacks, and Comorbidities—An Observational Cohort Study in 825 Patients
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Patients with chronic cluster headaches have higher scores than the general population and there is an association between headache syndromes and depression which require further investigation. Expand
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Serotonin receptor ligands: treatments of acute migraine and cluster headache.
  • P. Goadsby
  • Medicine
  • Handbook of experimental pharmacology
  • 2007
This work has shown that the triptans' major action is neuronal, with both peripheral and central trigeminal inhibitory effects, as well as actions in the thalamus and at central modulatory sites, such as the periaqueductal grey matter. Expand
Estimulación de nervio periférico en el tratamiento de diferentes tipo de cefaleas
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An open study is performed to investigate further the efficacy of topiramate in cluster headache prophylaxis and to suggest a strategy for preventing cluster headache attacks. Expand
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Patients with cluster headache offer a population of primary headache patients with devastating acute attacks of pain and the syndrome is stereotyped with effective evidence-based treatments that are prescribed in only half of patients having cluster headache. Expand
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These findings establish central nervous system dysfunction in the region of the hypothalamus as the primum movens in the pathophysiology of cluster headache and suggest that this type of headache should be regarded as a neurovascular headache. Expand
[Cluster headache].
  • Y. Takase
  • Medicine
  • Nihon rinsho. Japanese journal of clinical medicine
  • 2005
Cluster headaches are characterized by attacks of strictly unilateral severe pain which is orbital, supraorbital, temporal or in any combination of these sites associated with one or more of theExpand
Melatonin in the Preventive Treatment of Chronic Cluster Headache
  • M. Peres, T. Rozen
  • Medicine
  • Cephalalgia : an international journal of headache
  • 2001
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Specific hypothalamic activation during a spontaneous cluster headache attack
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Gabapentin for the Treatment and Prophylaxis of Cluster Headache
Gabapentin was effective in the treatment of a patient with cluster headache and further investigation of gabapentin compared with conventional treatments and placebo is warranted. Expand
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