Cluster headache: focus on emerging therapies

  title={Cluster headache: focus on emerging therapies},
  author={Manjit Singh Matharu and Peter J. Goadsby},
  journal={Expert Review of Neurotherapeutics},
  pages={895 - 907}
  • M. Matharu, P. Goadsby
  • Published 1 September 2004
  • Medicine, Psychology
  • Expert Review of Neurotherapeutics
Cluster headache is a strictly unilateral headache that occurs in association with cranial autonomic features. It is an excruciating syndrome and is probably one of the most painful conditions known to mankind with female patients describing each attack as being worse than childbirth. In most patients, it has a striking circannual and circadian periodicity. This disorder has a highly stereotyped clinical phenotype and responds to specific therapies, thereby underlying the importance of… 
Trigeminal autonomic cephalalgias. Part 1: cluster headache.
The Neuropsychology of Cluster Headache: Cognition, Mood, Disability, and Quality of Life of Patients With Chronic and Episodic Cluster Headache
There is little comprehensive evidence of the impact of cluster headache on quality of life, disability, mood, and cognitive function in both its episodic (ECH) and chronic (CCH) variants.
Cluster headache treatment dilemmas: The experts respond
A study of expert recommendations in response to standardized vignettes found that conventional treatment approaches to cluster headache are unsuccessful but expert recommendations are relevant but may not be easily accessible to treating clinicians.
Phenotype of Cluster Headache: Clinical Variability, Persisting Pain Between Attacks, and Comorbidities—An Observational Cohort Study in 825 Patients
The aim of the study was to analyze the severity and extent of the clinical symptoms of episodic and chronic cluster headaches with regard to their variability and to compare them with the requirements of the International Classification of Headache Disorders 3rd edition (ICHD-3) diagnostic criteria.
Depression Among Patients with Chronic Cluster Headaches
Patients with chronic cluster headaches have higher scores than the general population and there is an association between headache syndromes and depression which require further investigation.
Trigeminal autonomic cephalalgias: a review and implications for dentistry.
Although the prevalence of TACs is small, it is important for dentists to recognize the disorder and refer patients to a neurologist, to avoid the pitfall of administering unnecessary and inappropriate traditional dental treatments in an attempt to alleviate the neurovascular pain.
Serotonin receptor ligands: treatments of acute migraine and cluster headache.
  • P. Goadsby
  • Medicine
    Handbook of experimental pharmacology
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This work has shown that the triptans' major action is neuronal, with both peripheral and central trigeminal inhibitory effects, as well as actions in the thalamus and at central modulatory sites, such as the periaqueductal grey matter.
Peripheral Neurostimulation for the Treatment of Refractory Cluster Headache, Long‐Term Follow‐Up: Case Report
Cluster headache is a headache syndrome characterized by periodic episodes of intense headache with spontaneous remission, and occipital nerve stimulation for the successful management of medically refractory cases is utilizing.


Topiramate in Cluster Headache Prophylaxis: an Open Trial
An open study is performed to investigate further the efficacy of topiramate in cluster headache prophylaxis and to suggest a strategy for preventing cluster headache attacks.
Cluster headache: A prospective clinical study with diagnostic implications
Patients with cluster headache offer a population of primary headache patients with devastating acute attacks of pain and the syndrome is stereotyped with effective evidence-based treatments that are prescribed in only half of patients having cluster headache.
[Cluster headache].
  • Y. Takase
  • Medicine
    Nihon rinsho. Japanese journal of clinical medicine
  • 2005
Cluster headaches are characterized by attacks of strictly unilateral severe pain which is orbital, supraorbital, temporal or in any combination of these sites associated with one or more of the
Melatonin in the Preventive Treatment of Chronic Cluster Headache
  • M. Peres, T. Rozen
  • Medicine, Psychology
    Cephalalgia : an international journal of headache
  • 2001
It is demonstrated that melatonin could rapidly alleviate cluster attacks, but only in episodic cluster patients, and reported two chronic cluster headache patients who had both daytime and nocturnal attacks that were alleviated with melatonin.
Specific hypothalamic activation during a spontaneous cluster headache attack
Results of voxel-based morphometry support the role of the posterior hypothalamus in the pathogenesis of cluster headache because an increased gray matter density has been shown in this structure, but clinical and experimental data show NTG-provoked and spontaneous cluster attacks to be comparable.
Treatment of Cluster Headache with Topiramate: Effects and Side-Effects in Five Patients
Topiramate may have prophylactic properties for treating cluster headache at lower doses than needed in epilepsy therapy, but its clinical value is limited due to central nervous system side-effects.
Topiramate-treated cluster headache
Clinical findings in 10 cluster headache patients whose conditions improved when they took topiramate are reported, and the mechanism for this response may be related to gamma-aminobutyric acid augmentation.
Gabapentin for the Treatment and Prophylaxis of Cluster Headache
Gabapentin was effective in the treatment of a patient with cluster headache and further investigation of gabapentin compared with conventional treatments and placebo is warranted.
Cluster headache with aura
The frequency and characteristics of cluster headaches with aura among the population of patients with cluster headache treated in an outpatient neurology clinic suggest the participation of the central nervous system in this type of cluster headache.